The Bioinformatics of Mouse Mutant Resources

The objectives of this two-day hands-on activity are, among others, to show participants how to find critical information about their favourite genes and to help them understand gene structures in detail as well as the underlying experimental data supporting the annotation. In addition, participants are enabled to find mutant mouse resources for their genes of interest using the IKMC and similar resources, to search IMPC phenotypic databases such as EuroPhenome and to gain an understanding of the high-throughput phenotype data generated and the statistical approaches required to analyse it.

Workshops

• June 2012 MRC Mouse Network – Harwell, UK
• July 2012 European Advanced Course on Atherosclerosis – Hinxton, Cambridge, UK
• October 2012 Mouse Molecular Genetics – Asilomar, Pacific Grove, CA

Previous Workshops

• 6th – 7th December 2010 MRC Harwell, UK
• 26th – 27th June 2011 Mouse Genetics 2011 - Washington DC
• 20th September 2011 Mouse Molecular Genetics – Hinxton, Cambridge, UK

Advanced Courses

Genetic Manipulation of ES Cells

This course provides a comprehensive overview and practical laboratory experience of the genetic manipulation of mouse ES cells for a broad range of applications. Recent advances in genome informatics, recombineering, transposon technology and uses of conditional gene targeting will be covered in lectures by both instructors and invited expert speakers and through interactive demonstrations. Laboratory work will focus on the culture and transfection of ES cells, design and construction of gene targeting vectors from BACs by recombineering, genotyping of gene targeting events and the practical use of transposon technology. Participants will also be trained in the informatics and practical use of public gene targeting resources being produced by the IKMC.

31st October – 13th November 2011, Genetic Manipulation of ES Cells, Hinxton, Cambridge, UK