International Knockout Mouse Consortium

1st December 2008

UPDATE: The presentation slides from the training day are
attached to the bottom of this page.

A world wide mutagenesis effort is underway aimed at mutating virtually
all mouse genes for functional annotation of the genome. The cornerstones
of this international effort are the European EUCOMM project, the U.S. KOMP
project, the Canadian NorCOMM project and the Texas Institute for Genomic
Medicine (TIGM), which collectively form the International Knockout Mouse
Consortium (IKMC). The IKMC projects are exchanging data and materials to
establish a unique, comprehensive resource useful for scientists all over
the world.

To this international initiative, EUCOMM will contribute the largest fraction
of conditionally mutated genes and was the first project to recognize the
importance of conditional mutagenesis.

The international community is invited to make the most of the EUCOMM resource
by participating in a one-day EUCOMM training course. This course aims to enable
researchers to use and understand the extensive bioinformatics infrastructure
underpinning the EUCOMM pipeline. The course will be held at the Wellcome
Trust Sanger Institute.

Aimed at non-EUCOMM participants the course will cover the following topics:

1. A review of the EUCOMM production pipeline for making vectors for targeted conditional knockouts:
   • Targeting ES cells
   • The structure of conditional knockouts, deletions and insertions
   • Recombineering using the KO design
   • Gateway and beyond
   • Using the EUCOMM design tool to make your own recombineering designs
   • QC of targeting vectors and ES cells
2. Mapping and annotating EUCOMM gene-trap tags
3. Retrieving information from the EUCOMM website on genes, constructs and ES cells

The course will take place on December 1st, 2008 in the Rosalind Franklin Pavilion
at the Hinxton Hall Conference Centre, nr Cambridge, UK. Places and accommodation
are available for up to 40 people on a first-come-first-served basis.

A registration fee of €223.00 is payable, which covers accommodation and training;
a limited number of bursaries will be available for students and postdoctoral researchers.

To book your place, please contact eucomm@sanger.ac.uk.

Further information on travel and the venue can be found at http://hydra.hinxton.wellcome.ac.uk/introduction.html.