Home ยป Publications: Research using IKMC products

Publications: Research using IKMC products

2013

May 2013 Robust and sensitive analysis of mouse knockout phenotypes.
May 2013 2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.
May 2013 Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.
May 2013 Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.
April 2013 Novel reporter alleles of GSK-3alpha and GSK-3beta.
April 2013 The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis.
March 2013 Roles of Wnt8a during formation and patterning of the mouse inner ear.
March 2013 Dystroglycan organizes axon guidance cue localization and axonal pathfinding.
March 2013 Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.
March 2013 Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice.
March 2013 Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses.
March 2013 Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males.
March 2013 Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.
March 2013 Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.
February 2013 Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice.
February 2013 Ghrelin receptor expression and colocalization with anterior pituitary hormones using a GHSR-GFP mouse line.
January 2013 Absence of selenoprotein P but not selenocysteine lyase results in severe neurological dysfunction.
January 2013 Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia.
January 2013 TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver.
January 2013 TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.
January 2013 Integrin alpha9beta1 in airway smooth muscle suppresses exaggerated airway narrowing.
January 2013 Bromodomain-dependent stage-specific male genome programming by Brdt.

2012

December 2012 Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice.
December 2012 Treatment of erythropoietin deficiency in mice with systemically administered siRNA.
November 2012 Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
November 2012 The role of sphingosine-1-phosphate transporter Spns2 in immune system function.
November 2012 Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem.
November 2012 Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.
November 2012 Targeted deletion of Sost distal enhancer increases bone formation and bone mass.
November 2012 Interferon-beta-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF.
October 2012 Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.
October 2012 Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function.
October 2012 DC-derived TSLP promotes Th2 polarization in LPS-primed allergic airway inflammation.
October 2012 Anoxia-Induced NMDA Receptor Activation Opens Pannexin Channels via Src Family Kinases.
October 2012 Microglia Proliferation Is Controlled by P2X7 Receptors in a Pannexin-1-Independent Manner during Early Embryonic Spinal Cord Invasion.
October 2012 Gbeta3 is required for normal light on responses and synaptic maintenance.
October 2012 IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia.
October 2012 Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.
October 2012 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members.
October 2012 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.
October 2012 iRhom2 is required for the secretion of mouse TNFalpha.
September 2012 Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity.
September 2012 The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.
September 2012 HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria.
August 2012 Plac1 (placenta-specific 1) is essential for normal placental and embryonic development.
August 2012 GPCR activation of Ras and PI3Kgamma in neutrophils depends on PLCbeta2/beta3 and the RasGEF RasGRP4.
August 2012 SEC23B is required for the maintenance of murine professional secretory tissues.
August 2012 Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.
July 2012 A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.
July 2012 Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences.
July 2012 RDH10 oxidation of Vitamin A is a critical control step in synthesis of retinoic acid during mouse embryogenesis.
July 2012 The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.
June 2012 IFT25 Links the Signal-Dependent Movement of Hedgehog Components to Intraflagellar Transport.
June 2012 Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders.
June 2012 A novel biochemically salvageable animal model of hyperammonemia devoid of N-acetylglutamate synthase.
May 2012 ATP signaling is deficient in cultured pannexin1-null mouse astrocytes.
May 2012 Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
April 2012 MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.
April 2012 Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function.
April 2012 A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
April 2012 The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.
March 2012 Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity.
March 2012 Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation.
February 2012 Jarid1b targets genes regulating development and is involved in neural differentiation.
January 2012 The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.
January 2012 Control of B Cell Development by the Histone H2A Deubiquitinase MYSM1.
January 2012 A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.

2011

December 2011 Eye development genes and known syndromes.
December 2011 Disruption of a ciliary B9 protein complex causes Meckel syndrome.
November 2011 Targeting pannexin1 improves seizure outcome.
November 2011 Two non-vesicular ATP release pathways in the mouse erythrocyte membrane.
September 2011 Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia.
September 2011 Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
August 2011 TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons.
August 2011 Loss of the BMP Antagonist, SMOC-1, Causes Ophthalmo-Acromelic (Waardenburg Anophthalmia) Syndrome in Humans and Mice.
July 2011 Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
July 2011 The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene. (ERRATUM: personal communication)
July 2011 A conditional knockout resource for the genome-wide study of mouse gene function.
July 2011 Mammalian BTBD12 (SLX4) Protects against Genomic Instability during Mammalian Spermatogenesis.
June 2011 Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease.
May 2011 SPLUNC1 Promotes Lung Innate Defense Against Mycoplasma pneumoniae Infection in Mice.
April 2011 Obligate role for ketone body oxidation in neonatal metabolic homeostasis.
April 2011 High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.
February 2011 Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.
February 2011 DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.
February 2011 Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.
January 2011 Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.

2010

November 2010 Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin.
November 2010 Obtaining and Loading Phenotype Annotations from Europhenome
September 2010 The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene.

2009

June 2009 Agouti C57BL/6N embryonic stem cells for mouse genetic resources.