International Knockout Mouse Consortium

Enter the gene symbol into the search box on the upper right and search. The resulting query summary lists one record (row) for each gene that matches your query.

The Gene column displays the gene symbol, chromosome, and location.

The Knockout Project Status column displays the current status of the gene in the following knockout project pipelines: KOMP-CSD, KOMP-Regeneron, EUCOMM, NorCOMM. The "Details" link leads to a page that provides more information about knockout attempts for the gene.

The Other Resources column displays information about mutant ES cells and mice for the gene that are available through the International Mouse Strain Resource (IMSR) or the International Gene Trap Consortium (IGTC). Also listed are targeted mutations and other mutations recorded in MGI.

The gene status details page (reached by following the "Details" link from the results summary) includes status information about all knockout attempts for the selected gene. If knockout attempts have lead to the generation of a targeting vector, or to more advanced stages, links to graphics detailing targeting vector and allele designs are provided. If IKMC products are available, order links to the corresponding repositories are provided.

The Regeneron pipeline comprises the following statuses:

• Regeneron Selected
• Parental BAC Obtained
• Design Finished/Oligos Ordered
• Targeting Vector QC Completed
• Vector Electroporated into ES Cells
• ES cell colonies picked
• ES cell colonies screened / QC no positives
• ES cell colonies screened / QC one positive
• ES cell colonies screened / QC positives
• ES Cell Clone Microinjected
• Germline Transmission Achieved

A detailed description of the EUCOMM and CSD pipeline statuses is available here.

Mutant ES cells or mice for your gene generated by other projects (i.e. outside the IKMC effort) might already be publicly available from the International Gene Trap Consortium (IGTC) or through the International Mouse Strain Resource (IMSR). Please check the Other Resources column for this information.