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What are the IKMC allele types?
Summary of all IKMC allele types
The wild-type is represented as a transcript with three exons. The 'floxed' exon (the exon that will be deleted for the null allele) is exon number 2.
EUCOMM, KOMP-CSD Targeted mutations
EUCOMM and KOMP-CSD make both promoter-driven and promoterless...
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24 Aug, 2010
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How is the "critical" exon decided in CSD alleles?
A number of criteria are applied when choosing the critical exon for a KOMP-CSD or EUCOMM allele, but not every gene can have all criteria fulfilled:
1) The critical exon(s) is selected so that its floxing (removal) by application of Cre produces a frameshift in *every* protein-coding...
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27 Apr, 2011
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