IKMC Project Report - EUCOMM (ID: 117202)

Dnase1l2 MGI:1913955 ENSMUSG00000024136 OTTMUSG00000029900
Pre-pipeline Designs Vectors ES Cells Mice
Design Completed

Mice no data available

Mutagenesis Predictions

This gene has 6 wild type transcripts, of which 3 are protein-coding. Following removal of the floxed region, 3 transcripts are predicted to produce a truncated protein product of which 0 may be subject to non-sense mediated decay (NMD). The original allele for this mutation is of type ''. The table below shows the predicted structure of the gene transcripts after application of Flp and Cre (forming a 'Knockout-First, Post-Flp and Cre - Deletion, No Reporter' allele - more information on IKMC alleles can be found here). Click the 'view' button for each transcript to see the full prediction for that transcript.

Ensembl transcript id Ensembl Biotype Floxed transcript description Details
ENSMUST00000088506 protein_coding Residual N-terminal, residual C-terminal product view

Predicted translation:

MGWPWAPLTAVWALGVMGATALRIGAFNVQSFGDNKVSDPDCGSVIAQALAISDHFPVEVTFKTH*

Ensembl Exon ID Pfam Domains WildType Floxed
ENSMUSE00000775801 UTR UTR
ENSMUSE00000552806 Endo/exonuclease/phosphatase (26/254 aa) UTR + start codon + CDS UTR + start codon + CDS
ENSMUSE00000138614 Endo/exonuclease/phosphatase (30/254 aa) CDS Deleted
ENSMUSE00001015215 Endo/exonuclease/phosphatase (29/254 aa) CDS Deleted
ENSMUSE00001086653 Endo/exonuclease/phosphatase (35/254 aa) CDS Deleted
ENSMUSE00000973195 Endo/exonuclease/phosphatase (38/254 aa) CDS Deleted
ENSMUSE00000984344 Endo/exonuclease/phosphatase (84/254 aa) CDS Deleted
ENSMUSE00000306890 Endo/exonuclease/phosphatase (15/254 aa) CDS + stop codon + UTR CDS + stop codon + UTR
Legend: in frame deleted frameshifted
ENSMUST00000119932 protein_coding Residual N-terminal, residual C-terminal product view

Predicted translation:

MGWPWAPLTAVWALGVMGATALRIGAFNVQSFGDNKVSDPDCGSVIAQALAISDHFPVEVTFKTH*

Ensembl Exon ID Pfam Domains WildType Floxed
ENSMUSE00000716393 Endo/exonuclease/phosphatase (26/254 aa) UTR + start codon + CDS UTR + start codon + CDS
ENSMUSE00000138614 Endo/exonuclease/phosphatase (30/254 aa) CDS Deleted
ENSMUSE00001015215 Endo/exonuclease/phosphatase (29/254 aa) CDS Deleted
ENSMUSE00001086653 Endo/exonuclease/phosphatase (35/254 aa) CDS Deleted
ENSMUSE00000973195 Endo/exonuclease/phosphatase (38/254 aa) CDS Deleted
ENSMUSE00000984344 Endo/exonuclease/phosphatase (84/254 aa) CDS Deleted
ENSMUSE00000710721 Endo/exonuclease/phosphatase (15/254 aa) CDS + stop codon + UTR CDS + stop codon + UTR
Legend: in frame deleted frameshifted
ENSMUST00000154675 protein_coding No analysis available: incomplete transcript
ENSMUST00000148820 nonsense_mediated_decay No analysis available: incomplete transcript
ENSMUST00000129401 nonsense_mediated_decay No analysis available: incomplete transcript
ENSMUST00000153858 retained_intron No analysis available: incomplete transcript
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ES Cell Clones no data available

Targeting Vectors no data available

Intermediate Vectors no data available