IKMC Project Report - KOMP-CSD (ID: 46515)

Cdk12 MGI:1098802 ENSMUSG00000003119 OTTMUSG00000002637
Pre-pipeline Designs Vectors ES Cells Mice
Vector - Initial Attempt Unsuccessful

Mice no data available

Mutagenesis Predictions

This gene has 7 wild type transcripts, of which 4 are protein-coding. Following removal of the floxed region, 4 transcripts are predicted to produce a truncated protein product of which 4 may be subject to non-sense mediated decay (NMD). The original allele for this mutation is of type ''. The table below shows the predicted structure of the gene transcripts after application of Flp and Cre (forming a 'Knockout-First, Post-Flp and Cre - Deletion, No Reporter' allele - more information on IKMC alleles can be found here). Click the 'view' button for each transcript to see the full prediction for that transcript.

Ensembl transcript id Ensembl Biotype Floxed transcript description Details
ENSMUST00000107538 protein_coding No protein product (NMD) view

Predicted translation:

MPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDVGLVTPEAASLGTIIKPLVEYDDISSDS
DTFSDDTAFKSDRRENEERRGTDRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRVSGSSKRSVEGSDDY
GKAQLSKSGSKESRSSKMHKEKTRKERELKSGYKDRSKSHRKRETPKSYKTVASPKRRSRSPHRKWSDSSKQDDSPSGAS
YGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSG
RSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSR
KKKERAAAAAAAKMDGKESKSSPIILPKKEKLEVKESGLESKKLPRSIKSEKSTPDTELVTVAHSNPEVKHCLDTGKVRL
DENLQKHPAKDLKAQGTKDVKPVAPKEVIVTSKETETSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIPLQP
PLPPPQPPFSQVPVSSTSILPSSPHPRTSTLSSQTNSQPPVQVSMKTQVSITAAIPHLKTSTLPPLPLPPLLPGDDDMDS
PKETLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSPEPKAITPPQQPYKKRPKCLLPCI*

Ensembl Exon ID Pfam Domains WildType Floxed
ENSMUSE00000673532 UTR + start codon + CDS UTR + start codon + CDS
ENSMUSE00000577507 CDS CDS
ENSMUSE00000410772 CDS CDS
ENSMUSE00000577506 Prot_kinase_cat_dom (22/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (18/246 aa) CDS Deleted
ENSMUSE00000111355 Prot_kinase_cat_dom (58/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (58/246 aa) CDS Deleted
ENSMUSE00000577503 Prot_kinase_cat_dom (64/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (64/246 aa) CDS CDS + stop codon + UTR
ENSMUSE00000372883 Prot_kinase_cat_dom (20/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (20/246 aa) CDS
ENSMUSE00000577502 Prot_kinase_cat_dom (35/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (35/246 aa) CDS
ENSMUSE00000370141 Prot_kinase_cat_dom (27/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (27/246 aa) CDS
ENSMUSE00000111353 Prot_kinase_cat_dom (40/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (30/246 aa) CDS
ENSMUSE00000282909 Prot_kinase_cat_dom (34/293 aa) CDS
ENSMUSE00001091986 CDS
ENSMUSE00000972363 CDS
ENSMUSE00000673531 CDS + stop codon + UTR
Legend: in frame deleted frameshifted
ENSMUST00000107539 protein_coding No protein product (NMD) view

Predicted translation:

MPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDVGLVTPEAASLGTIIKPLVEYDDISSDS
DTFSDDTAFKSDRRENEERRGTDRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRVSGSSKRSVEGSDDY
GKAQLSKSGSKESRSSKMHKEKTRKERELKSGYKDRSKSHRKRETPKSYKTVASPKRRSRSPHRKWSDSSKQDDSPSGAS
YGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSG
RSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSR
KKKERAAAAAAAKMDGKESKSSPIILPKKEKLEVKESGLESKKLPRSIKSEKSTPDTELVTVAHSNPEVKHCLDTGKVRL
DENLQKHPAKDLKAQGTKDVKPVAPKEVIVTSKETETSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIPLQP
PLPPPQPPFSQVPVSSTSILPSSPHPRTSTLSSQTNSQPPVQVSMKTQVSITAAIPHLKTSTLPPLPLPPLLPGDDDMDS
PKETLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSPEPKAITPPQQPYKKRPKCLLPCI*

Ensembl Exon ID Pfam Domains WildType Floxed
ENSMUSE00000673534 UTR + start codon + CDS UTR + start codon + CDS
ENSMUSE00000577507 CDS CDS
ENSMUSE00000410772 CDS CDS
ENSMUSE00000577506 Prot_kinase_cat_dom (22/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (18/246 aa) CDS Deleted
ENSMUSE00000111355 Prot_kinase_cat_dom (58/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (58/246 aa) CDS Deleted
ENSMUSE00000577503 Prot_kinase_cat_dom (64/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (64/246 aa) CDS CDS + stop codon + UTR
ENSMUSE00000372883 Prot_kinase_cat_dom (20/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (20/246 aa) CDS
ENSMUSE00000577502 Prot_kinase_cat_dom (35/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (35/246 aa) CDS
ENSMUSE00000370141 Prot_kinase_cat_dom (27/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (27/246 aa) CDS
ENSMUSE00000111353 Prot_kinase_cat_dom (40/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (30/246 aa) CDS
ENSMUSE00000282909 Prot_kinase_cat_dom (34/293 aa) CDS
ENSMUSE00001091986 CDS
ENSMUSE00000972363 CDS
ENSMUSE00000673533 CDS + stop codon + UTR
Legend: in frame deleted frameshifted
ENSMUST00000003203 protein_coding No protein product (NMD) view

Predicted translation:

MPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDVGLVTPEAASLGTIIKPLVEYDDISSDS
DTFSDDTAFKSDRRENEERRGTDRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRVSGSSKRSVEGSDDY
GKAQLSKSGSKESRSSKMHKEKTRKERELKSGYKDRSKSHRKRETPKSYKTVASPKRRSRSPHRKWSDSSKQDDSPSGAS
YGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSG
RSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSR
KKKERAAAAAAAKMDGKESKSSPIILPKKEKLEVKESGLESKKLPRSIKSEKSTPDTELVTVAHSNPEVKHCLDTGKVRL
DENLQKHPAKDLKAQGTKDVKPVAPKEVIVTSKETETSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIPLQP
PLPPPQPPFSQVPVSSTSILPSSPHPRTSTLSSQTNSQPPVQVSMKTQVSITAAIPHLKTSTLPPLPLPPLLPGDDDMDS
PKETLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSPEPKAITPPQQPYKKRPKCLLPCI*

Ensembl Exon ID Pfam Domains WildType Floxed
ENSMUSE00000412328 UTR + start codon + CDS UTR + start codon + CDS
ENSMUSE00000577507 CDS CDS
ENSMUSE00000410772 CDS CDS
ENSMUSE00000577506 Prot_kinase_cat_dom (22/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (18/246 aa) CDS Deleted
ENSMUSE00000111355 Prot_kinase_cat_dom (58/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (58/246 aa) CDS Deleted
ENSMUSE00000577503 Prot_kinase_cat_dom (64/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (64/246 aa) CDS CDS + stop codon + UTR
ENSMUSE00000372883 Prot_kinase_cat_dom (20/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (20/246 aa) CDS
ENSMUSE00000577502 Prot_kinase_cat_dom (35/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (35/246 aa) CDS
ENSMUSE00000370141 Prot_kinase_cat_dom (27/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (27/246 aa) CDS
ENSMUSE00000111353 Prot_kinase_cat_dom (40/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (30/246 aa) CDS
ENSMUSE00000282909 Prot_kinase_cat_dom (34/293 aa) CDS
ENSMUSE00001091986 CDS
ENSMUSE00000366176 CDS + stop codon + UTR
Legend: in frame deleted frameshifted
ENSMUST00000092733 protein_coding No protein product (NMD) view

Predicted translation:

MPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDVGLVTPEAASLGTIIKPLVDPLPSRKSM
KSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKSSPIILPKKEKL
EVKESGLESKKLPRSIKSEKSTPDTELVTVAHSNPEVKHCLDTGKVRLDENLQKHPAKDLKAQGTKDVKPVAPKEVIVTS
KETETSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIPLQPPLPPPQPPFSQVPVSSTSILPSSPHPRTSTLS
SQTNSQPPVQVSMKTQVSITAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPAKKEKEQRTRHLLTDLPLPPELP
GGDPSPPDSPEPKAITPPQQPYKKRPKCLLPCI*

Ensembl Exon ID Pfam Domains WildType Floxed
ENSMUSE00000577497 UTR + start codon + CDS UTR + start codon + CDS
ENSMUSE00000963898 CDS CDS
ENSMUSE00000577507 CDS CDS
ENSMUSE00000410772 CDS CDS
ENSMUSE00000577506 Prot_kinase_cat_dom (22/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (18/246 aa) CDS Deleted
ENSMUSE00000111355 Prot_kinase_cat_dom (58/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (58/246 aa) CDS Deleted
ENSMUSE00000577503 Prot_kinase_cat_dom (64/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (64/246 aa) CDS CDS + stop codon + UTR
ENSMUSE00000372883 Prot_kinase_cat_dom (20/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (20/246 aa) CDS
ENSMUSE00000577502 Prot_kinase_cat_dom (35/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (35/246 aa) CDS
ENSMUSE00000370141 Prot_kinase_cat_dom (27/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (27/246 aa) CDS
ENSMUSE00000111353 Prot_kinase_cat_dom (40/293 aa) | Ser-Thr/Tyr_kinase_cat_dom (30/246 aa) CDS
ENSMUSE00000282909 Prot_kinase_cat_dom (34/293 aa) CDS
ENSMUSE00001091986 CDS
ENSMUSE00000972363 CDS
ENSMUSE00000577492 CDS + stop codon + UTR
Legend: in frame deleted frameshifted
ENSMUST00000145113 processed_transcript No analysis available: incomplete transcript
ENSMUST00000147441 processed_transcript Target region does not overlap transcript
ENSMUST00000125152 processed_transcript Target region does not overlap transcript
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ES Cell Clones no data available

Targeting Vectors no data available

Intermediate Vectors no data available