IKMC Project Report - KOMP-CSD (ID: 73270)

Cacna1i MGI:2178051 ENSMUSG00000022416 OTTMUSG00000034511
Pre-pipeline Designs Vectors ES Cells Mice
Vector Construction in Progress

Mice no data available

Mutagenesis Predictions

This gene has 6 wild type transcripts, of which 4 are protein-coding. Following removal of the floxed region, 4 transcripts are predicted to produce a truncated protein product of which 0 may be subject to non-sense mediated decay (NMD). The original allele for this mutation is of type ''. The table below shows the predicted structure of the gene transcripts after application of Flp and Cre (forming a 'Knockout-First, Post-Flp and Cre - Deletion, No Reporter' allele - more information on IKMC alleles can be found here). Click the 'view' button for each transcript to see the full prediction for that transcript.

Ensembl transcript id Ensembl Biotype Floxed transcript description Details
ENSMUST00000160424 protein_coding Residual N-terminal, residual C-terminal product view

Predicted translation:

MADSNLPPSSSAAPDPEPGITEQPGPRSPPPSPPGLEEPLDGTNPDVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPMVE
YSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEEN
FTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDMYDFGAGRQDLNASGLCVNWNRYYN
VCRTGNANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSET
KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQNRRQATGPGTPAPAKPGPHAKEP
SHCKLCPRHSPLDTTPHTLVQPISAILASDPSSCPRCQHEAGRRPSGLGSTDSGQEGSGSGGSAEAEANGDGPQSSEDGV
SSGLGKEEEQEDGAARLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFA
LEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVAT
FCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTTPWASLYFVA
LMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNLEELDKLPEGLDSSRDLKLCPIPMTPNGHLDPSLPLGGHL
GPAGAMGAAPRLSLQPDPVLVALESRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSGTWASRRSSWNSLKHKPPSAEHE
SLLSGERGGSCVRACEGAREDAPPRAAPLHAPHTHHAHHGPHLAHRHRHHRRTLSLDTRDSVDLAELVPVVGAHSRAAWR
AAGQAPGHEDCNGRMPNIAKDVFTKMDDRRDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENKFRILC
QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVL
DGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGIL
GVQLFKGKFYHCLGVDTRNITNRSDCVAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH
NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCPTRLLIHSM
CTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSV
MGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK
LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLIN
VVVAVLMKHLDDSNKEAQEDAEMDAEIELEMAHGLGPGPGPCPCPCPCPCPCPCPGPRMPTSSPGAPGRGSGGAGVGGDT
ESHLCRHCYSPAQETLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCDKCHHDKQEVQLAETEAFSLNSDRSSS
VLLGDDLSLEDPTACPQGPKESKGELEPPEPMQAGDLDECFFPFAGEPVSAGPESLLCEMGAIPFNPVQSWLKHESNQAP
PSPFSPDGSSPLLQMPAEFFHPAVSASQKGQEPGMSSGTLPKIALQGSWASLRSPSVNCTLLRQATVSDTSLDASPSSSA
GSLQTTLEDSLTLSDSPRRALGPPVQVPGPRASLSPATRRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTYHDSMDP
SDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCLPPTLPPPGLTPARKFSSTSSLAAGPGRPGATVSVRGLARSPSWAADR
SKDPPGQAQLASGFGSSAPEPQPPPGESTDAASKRKR*

Ensembl Exon ID Pfam Domains WildType Floxed
ENSMUSE00000865236 UTR UTR
ENSMUSE00000863049 UTR + start codon + CDS UTR + start codon + CDS
ENSMUSE00000852042 CDS Deleted
ENSMUSE00000557348 Ion_trans_dom (43/280 aa) CDS Deleted
ENSMUSE00000507185 Ion_trans_dom (34/280 aa) CDS CDS
ENSMUSE00000557347 Ion_trans_dom (54/280 aa) CDS CDS
ENSMUSE00000512639 Ion_trans_dom (106/280 aa) CDS CDS
ENSMUSE00000511828 Ion_trans_dom (31/280 aa) CDS CDS
ENSMUSE00000510780 Ion_trans_dom (15/280 aa) CDS CDS
ENSMUSE00000517152 CDS CDS
ENSMUSE00000557346 Ion_trans_dom (41/187 aa) CDS CDS
ENSMUSE00000257367 Ion_trans_dom (63/187 aa) CDS CDS
ENSMUSE00000257356 Ion_trans_dom (40/187 aa) CDS CDS
ENSMUSE00000557345 Ion_trans_dom (45/187 aa) CDS CDS
ENSMUSE00000680898 CDS CDS
ENSMUSE00000680896 CDS CDS
ENSMUSE00000467591 CDS CDS
ENSMUSE00000257318 CDS CDS
ENSMUSE00000557343 CDS CDS
ENSMUSE00000647670 Ion_trans_dom (14/223 aa) CDS CDS
ENSMUSE00000557341 Ion_trans_dom (62/223 aa) CDS CDS
ENSMUSE00000647669 Ion_trans_dom (43/223 aa) CDS CDS
ENSMUSE00000557339 Ion_trans_dom (42/223 aa) CDS CDS
ENSMUSE00000647668 Ion_trans_dom (30/223 aa) CDS CDS
ENSMUSE00000464849 Ion_trans_dom (33/223 aa) CDS CDS
ENSMUSE00000499041 CDS CDS
ENSMUSE00000482722 Ion_trans_dom (29/208 aa) CDS CDS
ENSMUSE00000481755 Ion_trans_dom (46/208 aa) | PKD1_2_channel (6/144 aa) CDS CDS
ENSMUSE00000557337 Ion_trans_dom (24/208 aa) | PKD1_2_channel (24/144 aa) CDS CDS
ENSMUSE00000557336 Ion_trans_dom (27/208 aa) | PKD1_2_channel (27/144 aa) CDS CDS
ENSMUSE00000501674 Ion_trans_dom (41/208 aa) | PKD1_2_channel (41/144 aa) CDS CDS
ENSMUSE00000460811 Ion_trans_dom (44/208 aa) | PKD1_2_channel (48/144 aa) CDS CDS
ENSMUSE00000680892 CDS CDS
ENSMUSE00000680891 CDS CDS
ENSMUSE00000966752 CDS CDS
ENSMUSE00001079204 CDS CDS
ENSMUSE00000869993 CDS + stop codon + UTR CDS + stop codon + UTR
Legend: in frame deleted frameshifted
ENSMUST00000160175 protein_coding Target region does not overlap transcript
ENSMUST00000161863 protein_coding Target region does not overlap transcript
ENSMUST00000162025 protein_coding Target region does not overlap transcript
ENSMUST00000162155 nonsense_mediated_decay No protein product (NMD) view

Predicted translation:

MADSNLPPSSSAAPDPEPGITEQPGPRSPPPSPPGLEEPLDGTNPDVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPMVE
YSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEEN
FTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDMYDFGAGRQDLNASGLCVNWNRYYN
VCRTGNANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSET
KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQNRRQATGPGTPAPAKPGPHAKEP
SHCKLCPRHSPLDTTPHTLVQPISAILASDPSSCPRCQHEAGRRPSGLGSTDSGQEGSGSGGSAEAEANGDGPQSSEDGV
SSGLGKEEEQEDGAARLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFA
LEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVAT
FCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTTPWASLYFVA
LMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNLEELDKLPEGLDSSRDLKLCPIPMTPNGHLDPSLPLGGHL
GPAGAMGAAPRLSLQPDPVLVALESRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSGTWASRRSSWNSLKHKPPSAEHE
SLLSGERGGSCVRACEGAREDAPPRAAPLHAPHTHHAHHGPHLAHRHRHHRRTLSLDTRDSVDLAELVPVVGAHSRAAWR
AAGQAPGHEDCNGRMPNIAKDVFTKMDDRRDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENKFRILC
QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVL
DGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGIL
GVQLFKGKFYHCLGVDTRNITNRSDCVAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH
NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCPTRLLIHSM
CTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSV
MGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK
LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLIN
VVVAVLMKHLDDSNKEAQEDAEMDAEIELEMAHGLGPGPGPCPCPCPCPCPCPCPGPRMPTSSPGAPGRGSGGAGVGGDT
ESHLCRHCYSPAQETLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCDKCHHDKQETGPRPSCWGMT*

Ensembl Exon ID Pfam Domains WildType Floxed
ENSMUSE00000867709 UTR UTR
ENSMUSE00000863049 UTR + start codon + CDS UTR + start codon + CDS
ENSMUSE00000852042 CDS Deleted
ENSMUSE00000557348 Ion_trans_dom (43/280 aa) CDS Deleted
ENSMUSE00000507185 Ion_trans_dom (34/280 aa) CDS CDS
ENSMUSE00000557347 Ion_trans_dom (54/280 aa) CDS CDS
ENSMUSE00000512639 Ion_trans_dom (106/280 aa) CDS CDS
ENSMUSE00000511828 Ion_trans_dom (31/280 aa) CDS CDS
ENSMUSE00000510780 Ion_trans_dom (15/280 aa) CDS CDS
ENSMUSE00000517152 CDS CDS
ENSMUSE00000557346 Ion_trans_dom (41/187 aa) CDS CDS
ENSMUSE00000257367 Ion_trans_dom (63/187 aa) CDS CDS
ENSMUSE00000257356 Ion_trans_dom (40/187 aa) CDS CDS
ENSMUSE00000557345 Ion_trans_dom (45/187 aa) CDS CDS
ENSMUSE00000680898 CDS CDS
ENSMUSE00000680896 CDS CDS
ENSMUSE00000467591 CDS CDS
ENSMUSE00000257318 CDS CDS
ENSMUSE00000557343 CDS CDS
ENSMUSE00000647670 Ion_trans_dom (14/223 aa) CDS CDS
ENSMUSE00000557341 Ion_trans_dom (62/223 aa) CDS CDS
ENSMUSE00000647669 Ion_trans_dom (43/223 aa) CDS CDS
ENSMUSE00000557339 Ion_trans_dom (42/223 aa) CDS CDS
ENSMUSE00000647668 Ion_trans_dom (30/223 aa) CDS CDS
ENSMUSE00000464849 Ion_trans_dom (33/223 aa) CDS CDS
ENSMUSE00000499041 CDS CDS
ENSMUSE00000482722 Ion_trans_dom (29/208 aa) CDS CDS
ENSMUSE00000481755 Ion_trans_dom (46/208 aa) | PKD1_2_channel (6/144 aa) CDS CDS
ENSMUSE00000557337 Ion_trans_dom (24/208 aa) | PKD1_2_channel (24/144 aa) CDS CDS
ENSMUSE00000557336 Ion_trans_dom (27/208 aa) | PKD1_2_channel (27/144 aa) CDS CDS
ENSMUSE00000501674 Ion_trans_dom (41/208 aa) | PKD1_2_channel (41/144 aa) CDS CDS
ENSMUSE00000460811 Ion_trans_dom (44/208 aa) | PKD1_2_channel (48/144 aa) CDS CDS
ENSMUSE00000680892 CDS CDS
ENSMUSE00000860667 CDS + stop codon + UTR CDS + stop codon + UTR
ENSMUSE00001069724 UTR UTR
ENSMUSE00001019473 UTR UTR
ENSMUSE00000853390 UTR UTR
Legend: in frame deleted frameshifted
ENSMUST00000162913 nonsense_mediated_decay Target region does not overlap transcript
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ES Cell Clones no data available

Targeting Vectors no data available

Intermediate Vectors no data available