International Knockout Mouse Consortium

The members of the International Knockout Mouse Consortium (IKMC) are working together to
mutate all protein-coding genes in the mouse using a combination of gene trapping and gene
targeting in C57BL/6 mouse embryonic stem (ES) cells.

The IKMC includes the following programs:

• Knockout Mouse Project (KOMP) (USA)
  
  • CSD, a collaborative team at the Children's Hospital Oakland Research Institute (CHORI), the Wellcome Trust Sanger Institute and the University of California at Davis School of Veterinary Medicine , led by Pieter deJong, Ph.D., CHORI, along with K. C. Kent Lloyd, D.V.M., Ph.D., UC Davis; and Allan Bradley, Ph.D. FRS, and William Skarnes, Ph.D., at the Wellcome Trust Sanger Institute.
  • Regeneron, a team at the VelociGene division of Regeneron Pharmaceuticals, Inc., led by David Valenzuela, Ph.D. and George D. Yancopoulos, M.D., Ph.D.
  
  
• European Conditional Mouse Mutagenesis Program (EUCOMM) (Europe)
• North American Conditional Mouse Mutagenesis Project (NorCOMM) (Canada)
• Texas A&M Institute for Genomic Medicine (TIGM) (USA)

Maintenance and Funding
This site is maintained by:

• International Knockout Mouse Consortium Data Coordination Center (I-DCC) supported by the European Union (Project number: 223592)
• Knockout Mouse Project Data Coordination Center (KOMP-DCC) supported by the National Institutes of Health (Grant number: NIH HG004074)

References:

• Commentary in Cell: A Mouse for All Reasons
• Commentary in Cell: A New Partner for the International Knockout Mouse Consortium
• Agouti C57BL/6N embryonic stem cells for mouse genetic resources