International Knockout Mouse Consortium

We have worked with MGI in registering KOMP and EUCOMM alleles and establishing official nomenclature. MGI now represents all alleles from KOMP and EUCOMM; for example,

• Aamp^{tm1a(KOMP)Wtsi} and
• Zap70^{tm2e(EUCOMM)Hmgu}.

IKMC allele information is updated on a weekly basis.

We have implemented an Advanced Search: As before, one can search for genes to look up the targeting pipeline status for these genes. In addition, one can now search for all genes that have reached a specific pipeline status in all or in specific IKMC pipelines.

We have streamlined and simplified the on-line KOMP project gene nomination form. Researchers can now link to the nomination form directly from the KOMP gene search results page. The form can be used to nominate a gene for a specific KOMP targeting strategy or to express interest in raising the priority of a gene that is already in the KOMP project but does not yet have vectors, ES cells, or mice ready for distribution.

To access the new gene nomination form, start with a gene search.

We have streamlined the display of search / browse results and developed new

The KOMP database includes all genes from the Mouse Genome Informatics (MGI) database for which sequences and genome coordinates are available. This now includes all genes predicted by the NCBI, Ensembl, and Vega (Vertebrate Genome Annotation) pipelines for mouse Genome Build 37. All gene coordinates and all Vega IDs, Ensembl IDs, and Entrez Gene IDs have been updated accordingly.

The KOMP web site and navigation tools have been redesigned and new content was added.

The home page provides a quick summary of what one can do at the KOMP Web site. The new search tool permits direct queries against the KOMP database. An improved navigation bar provides quick access to information about KOMP, frequently asked questions (FAQs), and to the KOMP Repository.

Previously, we released new versions of the KOMP gene list on a monthly basis and searches were directed against the most recent version of this gene list. Queries had to match official gene symbols or gene IDs in order to be successful.

The new search functionality allows you to:

• Search the KOMP database directly, i.e. you will always obtain the most current information.
• Search all the genes in the KOMP database
• Search by gene symbol, gene IDs, gene name, old gene names and symbols, as well as synonyms
• Search by genome coordinates

The National Institutes of Health (NIH) announced today it will provide $4.8 million to establish and support a repository for its Knockout Mouse Project. This award is the final component of a more than $50 million trans-NIH initiative to increase the availability of genetically altered mice and related materials. The University of California, Davis (UC Davis) and Children

Three major mouse knockout programs are underway worldwide, working together to mutate all protein-encoding genes in the mouse using a combination of gene trapping and gene targeting in mouse embryonic stem (ES) cells. Although the current emphasis is on production of this valuable resource, there are significant efforts to facilitate program coordination, to enhance the availability of this resource, and to plan for future efforts in mouse genetics research.
Read more