EUCOMM

EUCOMM - The European Conditional Mouse Mutagenesis Program is founder member and European cornerstone of the International Knockout Mouse Consortium (IKMC).
EUCOMM contributes the largest fraction of conditionally trapped and targeted genes in mouse C57BL/6N embryonic stem (ES) cells to the IKMC.
EUCOMM vectors, mutant ES cells and mutant mice are distributed worldwide, enabling functional genomics research in a standardized and cost-effective manner by a much wider biomedical research community than has been possible previously.
EUCOMM mutant ES cells and vectors can be obtained from the European Mouse Mutant Cell Repository (EuMMCR).
EUCOMM mutant mice are archived and distributed by the European Mouse Mutant Archive (EMMA).

EUCOMM Farewell Meeting Participants

EUCOMM Project Information

Main Objectives

• Generation, archiving, and world-wide distribution of up to 12.000 conditional mutations across the mouse genome in mouse embryonic stem (ES) cells
• Establishment of a limited number of mouse mutants from this resource

Mutagenesis Strategies

• Conditional gene trapping - random approach for expressed genes
• Conditional targeted trapping - directed approach, used for expressed genes
• Conditional gene targeting - directed approach, used for non-expressed genes

Networking

• Generation of European mouse functional genomics platform by synergistic integration of EMMA, EUMODIC, EURExpress, FLPFLEX ,FunGenES, PRIME and others
• Cornerstone of world-wide mouse mutagenesis effort, member of the International Knockout Mouse Consortium (IKMC)

Societal Benefits

• Improvement of health research
• Speedup of drug development, therapy and diagnosis
• Competitive advantage for pharmaceutical industry

Funding & Structure

• Funded by European Union (FP 6, Priority 1 "Life Sciences, Genomics and Biotechnology for Health")
• EU funding: up to 13 million Euros
• Integrated Project
• Consortium: 9 participants from four European countries